The uterus plays a role in memory, study finds

New research conducted in an animal model has uncovered an intriguing fact about the uterus, namely that it seems to interact with the brain and affect memory.

The uterus may have other roles beyond reproduction, new research suggests, and removing the uterus could affect memory.

The best-known role of the uterus is its function in pregnancy, but does it serve any other purpose beyond that of reproduction?

So far, textbooks of obstetrics and gynecology have stated that, outside of pregnancy, the uterus lies in a dormant state, and does not interact with other organs.

However, new research from Arizona State University in Tempe may soon alter definitions referring to the function of this organ.

In a study on the rat model, senior author Prof. Heather Bimonte-Nelson and colleagues demonstrated that removing the uterus — a surgical procedure known as hysterectomy — has a definite impact on spatial memory.

These findings, which appear in the journal Endocrinology, suggest that this organ communicated with the brain, influencing some cognitive processes.

“There is some research showing that women who underwent hysterectomy but maintained their ovaries had an increased risk for dementia if the surgery occurred before natural menopause,” Prof. Bimonte-Nelson notes.

[inline_divider type=”1″] This finding is striking. We wanted to investigate and understand whether the uterus itself could impact brain function.” [inline_divider type=”1″]


The uterus communicates with the brain

While many people may know that the uterus and the ovaries have a connection due to their joint role in reproduction, they may not be aware of the links between the uterus and the brain.

Prof. Bimonte-Nelson explains that the body’s autonomic nervous system, which regulates “automated” metabolic processes, such as heart rate, breathing, digestion, and sexual arousal, also has links to the uterus and brain.

Starting from this connection between the uterus and the brain, the researchers wanted to know if the two interact in unobvious ways, and if removing the uterus would impact cognitive function.

To do so, the investigators used female rats, which they divided into four groups. The rats in three of these groups underwent surgeries that mimicked the oophorectomies (surgical removal of the ovaries) and hysterectomies (surgical removal of the uterus) in humans.